Seven minutes before the break, Esteghlal went 2-0 ahead as Ghaedi sent a cross from the right flank into the far post for Ali Karimi who evaded his marker and converted a header.
Joan Simun Edmundsson's sole goal was enough to ensure Arminia Bielefeld a 1-0 win over Cologne, and RB Leipzig played out a 1-1 draw with Bayer Leverkusen. Enditem
Semedo's sale to Wolverhampton Wanderers means the defense virtually picks itself with Sergi Roberto, Jordi Alba, Gerard Pique and Clement Lenglet continuing together, while Ter Stegen's knee operation means Norberto Neto will make a rare start.
For its part, Femexfut said it hoped to set up a clash against another opponent on September 30.
The top four teams at the end of the qualifying tournament will automatically book a place in football's showpiece tournament. The fifth-ranked side will advance to a two-legged intercontinental playoff.
Having lost cornerstones such as Thiago Alcantara (Liverpool), Ivan Perisic (Inter), Javi Martinez (Bilbao), and Philippe Coutinho (Everton), Flick intends to update its midfield options.
Chelsea were the summer's big spenders and the game was a big test of both their and Liverpool's title credentials, but things swung dramatically Liverpool's way as Andreas Christensen was sent off for pulling Mane back when he was through on goal in the first half injury time.
Chengdu was the only side who had pocketed three wins consecutively in the first three rounds of the league.
Guangzhou Evergrande already secured the first position in this division by 31 points. However, the second and third position also see fierce competition between Jiangsu and Shandong, who gained the same number of points and are ranked only on goal difference. Enditem
Opponent Real Betis has started the campaign well under Manuel Pellegrini and the former Real Madrid coach looks to have added steel to a side which flattered to deceive last season.
Bruno Labbadia's men gained momentum but Frankfurt stood firm and protected its lead until the final whistle.